View abstract. Oral Intake of Enzymatically Decomposed AP Collagen Peptides Improves Skin Moisture and Ceramide and Natural Moisturizing Factor Contents in the Stratum Corneum. Ingredients such as dyes and synthetic gelatin found in gummy supplements can be difficult to digest, leading to inflammation of the gut. Collagen supplements The best vitamins for skin include vitamins C, D, and E. People can get many of these vitamins from their diet or by taking supplements. In studies, collagen peptide supplements have been shown to support skin elasticity 5 and overall hydration 6 . As a person ages and collagen production slows, bones can become weaker as the person loses the collagen necessary to keep the bones strong and supported. pii: E482. Collagen Peptides: What They Can and Can't Do for Real - Greatist A 2016 animal study also found that collagen hydrolysate (also called collagen peptides) reduced fat cell size and weight gain in rats. Complementary Medicine / Alternative Medicine, http://www.jmnn.org/article.asp?issn=2278-1870;year=2015;volume=4;issue=1;spage=47;epage=53;aulast=Borumand, https://www.versusarthritis.org/about-arthritis/complementary-and-alternative-treatments/types-of-complementary-treatments/collagen/, https://www.ncbi.nlm.nih.gov/pubmed/25314004, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793325/, http://www.scielo.br/pdf/rbgg/v19n1/1809-9823-rbgg-19-01-00153.pdf, https://www.ncbi.nlm.nih.gov/pubmed/23949208, https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.12450, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429168/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594048/. Can Collagen Cause Diarrhea? Evaluation of the Effects of BioCell Collagen, a Novel Cartilage Extract, on Connective Tissue Support and Functional Recovery From Exercise. Given that glutamic acid is one of the amino acids present in the collagen protein, eating too many collagen peptides may indirectly lead to an unwanted headache. Lpez-Martnez MI, Miguel M, Garcs-Rimn M. Front Nutr. Disclaimer. Shigemura Y, Iwasaki Y, Tateno M, et al. The site is secure. View abstract. Its always something For most people, taking collagen peptide supplements should not have any major effects or health consequences, and topical collagen peptide products in particular are unlikely to pose a risk. Federal government websites often end in .gov or .mil. However, it is important to understand what collagen and biotin are and what research is available to support these claims. The site is secure. Schauss AG, Stenehjem J, Park J, Endres JR, Clewell A. Borumand, M., & Sibilla, S. (2015). HHS Vulnerability Disclosure, Help How Collagen Affects Inflammation: Collagen for Joint OTHER NAME(S): Collagen Hydrolysate, Collagen Peptidesi, Collagn, Collagen peptides have most often been used by adults in doses of 2.5-10 grams daily for up to 6 months. Nutrients. Collagen peptides powder may also cause headaches, dizziness, or lightheadedness in some users. View abstract. In rare cases, a peptide allergy can occur. 2010;340(5):360-6. The vegan options may not be available everywhere, but many are available online. The less your body has to work to break down the collagen when you consume it, the less likely you are to get a stomach ache or other unwanted side effects. 2020;72(3):125-130. WebGlutamate is implicated in cortical spreading depression, trigeminovascular activation, and central sensitization. 2014;27(3):113-9. doi: 10.1159/000355523. J Clin Densitom 2021. 2019;12(1):50. 2020;7:580918. Of those side effects, there has been a recurring theme among many collagen users asking: For instance, our liquid collagen supplement, ProT Gold, is actually recognized as a medical food, which is why it has a, nutritional label, not a supplement label. Bruyre O, Zegels B, Leonori L, et al. Unable to load your collection due to an error, Unable to load your delegates due to an error. Collagen Urinary Hydroxyproline Is Only Suitable As a Biomarker for Acute Intake, Up to 6 hr Postingestion of Collagen Proteins in "Free-Living," Healthy, Active Males. Collagen Int J Dermatol 2021;60(12):1449-1461. Maia Campos PMBG, Melo MO, Siqueira Csar FC. Insulin is an example of a peptide drug, which is composed of 51 amino acids. 2011;35(3):341-8. Li X, He Z, Xu J, Su C, Xiao X, Zhang L, Zhang H, Li H. Foods. pii: E76. Prowting JL, Bemben D, Black CD, Day EA, Campbell JA. 8600 Rockville Pike Nutrients. Bethesda, MD 20894, Web Policies Medical News Today only shows you brands and products that we stand behind. Peptides are also used in View abstract. Sangsuwan W, Asawanonda P. Four-weeks daily intake of oral collagen hydrolysate results in improved skin elasticity, especially in sun-exposed areas: a randomized, double-blind, placebo-controlled trial. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Collagen is one of the most plentiful proteins in mammals. 2018 Apr;15(2):361-370. doi: 10.1007/s13311-018-0616-5. Heart failure: Could a low sodium diet sometimes do more harm than good? The protein collagen has 3 essential amino acids that decrease constipation, helps with leaky gut syndrome, and even reduces diarrhea. 2020;12(3):618.View abstract. Prokopov A, Pavlackov J, Mokrejs P, Gl R. Collagen Hydrolysate Prepared from Chicken By-Product as a Functional Polymer in Cosmetic Formulation. What Are Peptides and What Are They Used For? - health.com View abstract. Looking older: fibroblast collapse and therapeutic implications. Mohammed A, He S. A Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy of a Hydrolyzed Chicken Collagen Type II Supplement in Alleviating Joint Discomfort. Clipboard, Search History, and several other advanced features are temporarily unavailable. Ranchordas MK, Rogerson D, Soltani H, Costello JT. J Dermatol Sci. That being said, we want to point out that these side effects are not common. 2018;17(2):298-304. Prowting JL, Bemben D, Black CD, Day EA, Campbell JA. The researchers found that the women taking the calcium and the collagen had lower levels of a protein responsible for breaking down bones in their blood. Collagen peptides are used as a bioactive ingredient in nutricosmetic products and have been shown in preclinical studies to improve skin barrier function, to induce the synthesis of collagen and hyaluronic acid, and to promote fibroblast growth and migration. Learn about some top options here. Unable to load your collection due to an error, Unable to load your delegates due to an error. Your Collagen Supplement Causing Headaches Lampropoulou-Adamidou K, Karlafti E, Argyrou C, et al. Most people can take collagen supplements without Nutrition is a key factor influencing skin health and consequently its appearance. Health Benefits of Collagen: Pros and Cons, Nutrition, and More Zhu CF, Li GZ, Peng HB, Zhang F, Chen Y, Li Y. ANSWER: Collagen and biotin supplements appear to be getting attention in the media for promoting healthy aging, along with joint and bone health. Others may experience side effects causing issues with the skin or digestive system, among other problems, but the likelihood of this is based largely on the quality of your chosen collagen peptides product. These preclinical and clinical observations argue for a strong link between migraine and the glutamatergic system, a link that is important to further characterize in an effort to better understand migraine mechanisms and deliver effective therapies. Tajti J, Szok D, Nagy-Grocz G, Tuka B, Petrovics-Balog A, Toldi J, Vecsei L. Curr Med Chem. Journal of Cosmetic Dermatology Published by Wiley Periodicals, Inc. Maturitas. Yes. However, these claims do not have backing by scientific research. Koizumi S, Inoue N, Sugihara F, Igase M. Effects of collagen hydrolysates on human brain structure and cognitive function: A pilot clinical study. Then, we recommend you evaluate the supplement itself along with the dosage you have been using., Not all collagen supplements are created equal and whether collagen can cause headaches may have more to do with the type of collagen you use and its bioavailability to you., When looking at the quality of a collagen supplement, first and foremost check to see if the company can back up their claims., If a company is making any kind of result claims regarding collagens ability to help resolve issues (especially medical issues) then they need to have resources, case studies, and other research to back up these claims., Since the FDA does not regulate collagen supplements as closely as they should, a lot of this is left up to the consumer to identify and sift through. 2022 Sep 16;11(18):2869. doi: 10.3390/foods11182869. Can Collagen Cause High Triglycerides. Licensed Natural Health Products Database. Also, Collagen Peptides supplements have not been found to cause any significant health risks for the majority of consumers. View abstract. Can Collagen Can Collagen Supplements Cause High Cholesterol collagen peptides Copper Peptides * "It The effect of a hydrolyzed collagen-based supplement on wound healing in patients with burn: A randomized double-blind pilot clinical trial. Skin rashes. 2015;8:29-42. 2018;10(1). J Cosmet Dermatol. Sci Rep. 2018;8(1):11403. 2019 Jan;98(3):e14099. Collagen is a type of structural protein in the body. Int J Sport Nutr Exerc Metab. Kim DU, Chung HC, Choi J, Sakai Y, Lee BY. A person should choose the supplement that best supports their goals when picking a collagen type. WebThis study examined whether consuming collagen peptides (CP) before and after strenuous exercise alters markers of muscle damage, inflammation and bone turnover. 2019;11(1). Careers. View abstract. Asserin J, Lati E, Shioya T, Prawitt J. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. Nutrients. Unfortunately, experts say that the research supporting all of these claims is limited. Although rare and typically mild, side effects of collagen peptides on skin often take the form of inflammation and skin breakouts or rashes. Epub 2015 Nov 4. Can diet help improve depression symptoms? doi: 10.1097/MD.0000000000014099. Potential Cosmetic Active Ingredients Derived from Marine By-Products. View abstract. FASEB Experimental Biology 2004 Abstracts, Washington DC, April 17-21, 2004; A90. View abstract. Best collagen supplement for a variety of flavors: Care/Of Collagen Packs. What exactly is the reason collagen can cause a headache? Aczl T, Benczik B, gg B, Krtsi T, Urbn P, Bauer W, Gyenesei A, Tuka B, Tajti J, Ferdinandy P, Vcsei L, Blcskei K, Kun J, Helyes Z. J Headache Pain. J Cosmet Dermatol. J Cosmet Dermatol. Migraine pain-relay centers, including the trigeminal ganglion, trigeminal nucleus caudalis, and thalamus, contain glutamate-positive neurons, and glutamate activates the trigeminal nucleus caudalis. Although some experts believe that peptide skin creams or moisturizers are not able to be absorbed fully via the skin, instead recommending oral supplements, some research has nonetheless shown them to have positive effects on skin health. pii: E97. Cardiovascular health: Insomnia linked to greater risk of heart attack. Theres currently 80 approved peptide drugs worldwide. Collagen Peptides View abstract. Molecules 2021;26(16):4880. View abstract. Side effects vary depending on which type of collagen supplement you take, but they are generally minor overall. Print 2018 Dec 21. Part of this simply has to do with your individual body and the interactions it has with certain ingredients and substances., How much collagen you take, when you take it, and the combination of other genetic factors or medications you take can also influence the severity of the side effects you may experience when taking a collagen supplement., Through general anecdotal evidence, it does seem like collagen users often struggle with side effects, like headaches or bloating, when taking collagen supplements on a daily basis and when taking collagen in the whole form (i.e., bone broth)., Some of the most commonly reportedcollagen side effects may include:. Looking at the ingredients we find, they are natural, gluten-free, non-GMO, dairy-free, grass-fed pasture-raised cows, and wild-caught fish, and cage-free chickens. If you buy through links on this page, we may earn a small commission Heres our process. The easiest way to narrow down the absorption rate of a collagen protein is to see if it is hydrolyzed or not., Hydrolyzed or nano hydrolyzed collagen protein supplements, like ProT Gold, are easier to digest because the molecules are smaller and easier for your body to break down.. Front Nutr. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. A person can also use collagen supplements while following a keto diet plan. Hakuta A, Yamaguchi Y, Okawa T, Yamamoto S, Sakai Y, Aihara M. Anti-inflammatory effect of collagen tripeptide in atopic dermatitis. Whey protein but not collagen peptides stimulate acute and longer-term muscle protein synthesis with and without resistance exercise in healthy older women: a randomized controlled trial. Camilion JV, Khanna S, Anasseri S, Laney C, Mayrovitz HN. Hydroxyproline, (a key amino acid found in that collagen), can be converted into oxalate and excreted through the kidneys. The role of glutamate and its receptors in migraine. Whether or not collagen supplements are effective depends on what a person uses collagen for. Additionally, collagen contains various animal proteins, which can cause allergic reactions in some people. official website and that any information you provide is encrypted However, more research is necessary to prove the effects of collagen in supporting heart health. 2018;16(12). A randomized double blind clinical pilot trial evaluating the safety and efficacy of hydrolyzed collagen type II in adults with osteoarthritis. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 2020;111(3):708-718. Of those side effects, there has been a recurring theme among many collagen users asking: can taking collagen cause headaches? When following the proper dosage with a high-quality liquid collagen, though, you are less likely to experience adverse side effects., Whether collagen can cause headaches or not is a great question to be asking, especially when trying to decide which supplements are right for you and your body. Cneo F, Costa-Paiva L, Pinto-Neto AM, Morais SS, Amaya-Farfan J. Manufacturers tend to produce them using the bones and protein of animals. By following these tips, you can help ensure safe use of collagen peptides powder and minimize the risk of side effects or health issues. Dolan E, Dumas A, Keane KM, Bestetti G, Freitas LHM, Gualano B, Kohrt WM, Kelley GA, Pereira RMR, Sale C, Swinton PA. Sports Med. Glutamate receptor-subtype antagonists are effective in preclinical models of migraine, and in the clinic. Apart from fatigue, this might lead to headaches and feelings of nervousness and irritability. The two most commonly proposed benefits of collagen peptides are improved skin health and reduced joint pain. Therapeutic effects of marine collagen peptides on Chinese patients with type 2 diabetes mellitus and primary hypertension. 2006;19(2):92-6. The .gov means its official. 2015;114(8):1237-45. 2020:1-6. Oral Supplementation of Specific Collagen Peptides Combined with Calf-Strengthening Exercises Enhances Function and Reduces Pain in Achilles Tendinopathy Patients. Collagen supplements: Benefits, safety, and effects - Medical Rheumatoid arthritis, lupus, dermatomyositis and scleroderma are autoimmune, connective tissue diseases known to damage collagen. The oral supplementation with collagen peptides is efficacious to improve hallmarks of skin aging. "The riskiest side effects of any treatment are usually allergic Other potential side effects of collagen peptides in individuals with sensitivities or for those using poor quality collagen products include the following: If you are sensitive to the free glutamic acid found in collagen protein, you may experience mild headaches or have difficulty sleeping. https://webprod5.hc-sc.gc.ca/lnhpd-bdpsnh/info.do?licence=80034311&lang=eng. View abstract. 2010;35(6):797-804. Biosci Biotechnol Biochem. There were no statistically significant effects for the other dependent variables (P > 0.05). Trc T, Bohmov J. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). Zehra A, Burns J, Liu CK, et al. Mar Drugs. Oral collagen supplementation for skin aging: A fad or the future? 2021 Jan 1;31(1):32-39. doi: 10.1123/ijsnem.2020-0149. One review of the research into collagen supplementation found that using hydrolyzed collagen supplements helps promote joint health and potentially restore some bone density in people with osteoporosis and osteoarthritis. Neurotherapeutics. Benefits of sunlight: a bright spot for human health. Collagen is the most important structural protein in the body, critical to skin firmness, elasticity, and an overall youthful appearance. View abstract. This may cause a range of digestive issues including diarrhea, a general feeling of heaviness in the stomach, feelings of fullness, and heartburn. Background: Skin Pharmacol Physiol. Effect of Collagen Hydrolysate and Fish Oil on High-Sensitivity C-Reactive Protein and Glucose Homeostasis in Patients with severe Burn; a Randomized Clinical Trial. Collagen supplements have the potential to cause both headaches and migraines. Collagen loss with age can cause increased tooth sensitivity and decreased tooth strength. Zdzieblik D, Oesser S, Knig D. Specific Bioactive Collagen Peptides in Osteopenia and Osteoporosis: Long-Term Observation in Postmenopausal Women. Scientists describe collagenous colitis as a type of microscopic colitis because the inflammation it causes is only noticeable under a microscope. View abstract. All rights reserved. Keywords: Some other potential things that collagen may help with include: Collagen supplements come in a variety of types. Effectiveness of eye movement exercise and diaphragmatic breathing with jogging in reducing migraine symptoms: A preliminary, randomized comparison trial. Marine collagen supplements. Dizziness. Unauthorized use of these marks is strictly prohibited. Expert Opin Investig Drugs. It is responsible for several biological functions, one of which is to provide structural support in connective tissue, muscle, and skin. The participants engaged in regular exercise for 12 weeks. Topical application and oral supplementation of peptides in the improvement of skin viscoelasticity and density. Collagen peptide supplements can however lead to dermatological, digestive side, and other side effects, particularly in products with poorly sourced ingredients. Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Skin Pharmacol Physiol. HIGH CHOLESTEROL on Keto Diet (My 4-Year High Fat Diet Results!) Guerrero-Toro C, Koroleva K, Ermakova E, Gafurov O, Abushik P, Tavi P, Sitdikova G, Giniatullin R. Int J Mol Sci. The answer is yes., a study published in the Journal of the American Medical Association, found that people who took collagen-based Eur J Appl Physiol. Jendricke P, Kohl J, Centner C, Gollhofer A, Knig D. Influence of specific collagen peptides and concurrent training on cardiometabolic parameters and performance indices in women: A randomized controlled trial. Zhu CF, Li GZ, Peng HB, Zhang F, Chen Y, Li Y. Sports Med Open. So as you see, collagen can cause headaches and other issues in some people. Collagen Amino Acids 2019;51(4):691-704. 2019;11(4). 2015;14(3):30-8. Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing. All rights reserved. Kumar S, Sugihara F, Suzuki K, Inoue N, Venkateswarathirukumara S. A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis. Collagen supplements have the potential to cause both headaches and migraines., According to a few case studies on using collagen to treat osteoarthritis, when participants were using the collagen supplement, they did report a lower pain level in their joints but among the most commonly reported side effects was a headache from time to time.. Miyanaga M, Uchiyama T, Motoyama A, Ochiai N, Ueda O, Ogo M. Oral Supplementation of Collagen Peptides Improves Skin Hydration by Increasing the Natural Moisturizing Factor Content in the Stratum Corneum: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Urinary Metabolomics in Young Soccer Players after Winter Training Season. Int J Sport Nutr Exerc Metab. Collagen is concentrated in bones, ligaments, tendons, skin, blood Collagen benefits for skin and hair.*. 2017 Dec 14;12(12):CD009789. Appl Physiol Nutr Metab. Bone mineral density is key to preventing bone fractures. But does collagen have any side effects, and can collagen cause headaches?. Can Collagen Cause Accessibility Lee SK, Posthauer ME, Dorner B, Redovian V, Maloney MJ. Effects of collagen peptides on recovery following eccentric exercise in resistance-trained males-A pilot study. 5 Collagen Side Effects You Need to Know About by Zen Principle WebClinical research has also shown that daily supplementation with collagen peptides can increase bone mineral density, especially in calcium-deficient or osteopenic subjects 7. View abstract. These chemical ingredients can cause systemic inflammation as well as accumulate within the body, leading to enlarged and clogged pores, and ultimately more breakouts. 2004;26(3-4):105-11. Are they safe, and do they work? Collagen supplementation is generally safe with no reported adverse events. These types of ingredients and additives found in supplements can also be a reason why someone gets a headache versus the collagen molecules themselves., Next, looking at the absorption rate can help you avoid other side effects like bloating or an upset stomach. The participants skin hydration and elasticity also improved significantly. sharing sensitive information, make sure youre on a federal Both effects persisted after 12 weeks. Federal government websites often end in .gov or .mil. National Library of Medicine The effects of collagen peptides on muscle damage - PubMed An official website of the United States government. National Library of Medicine Webcan collagen supplements cause headaches? Role of collagen hydrolysate in bone and joint disease.Semin Arthritis Rheum 2000;30:87-99. This Czajka A, Kania EM, Genovese L, et al. WebCollagen is a nutritional supplement made from animal or fish materials. Peptides and transmitted securely. Collagen formula with Djulis for improvement of skin hydration, brightness, texture, crow's feet, and collagen content: A double-blind, randomized, placebo-controlled trial. View abstract. Nutrients. Although they are most popularly used to combat the signs of aging in the skin, collagen peptides can provide a number of other potential benefits as well. View abstract. Skin antiageing and systemic redox effects of supplementation with marine collagen peptides and plant-derived antioxidants: a single-blind case-control clinical study. As with any supplement, collagen supplements do have some potential side effects, especially when taken in excess. WebThis study examined whether consuming collagen peptides (CP) before and after strenuous exercise alters markers of muscle damage, inflammation and bone turnover. Alcock RD, Shaw GC, Tee N, Welvaert M, Burke LM. This site needs JavaScript to work properly. Before Int J Sport Nutr Exerc Metab 2021. View abstract. View abstract. Lis DM, Baar K. Effects of Different Vitamin C-Enriched Collagen Derivatives on Collagen Synthesis. The researchers theorized that collagen helped stimulate the production of the proteins responsible for muscle growth. Int J Mol Sci. government site. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Unfortunately, our bodies produce about 1% less collagen 1 with each passing year, and we're 2020;20(1):12-17.View abstract. Role of collagen hydrolysate in bone and joint disease. Biosci Rep. 2018 Dec 14;38(6):BSR20181347. Because the law does not require cosmetics to be approved by the FDA (Food and Drug Administration), topical skin care products containing collagen peptides are not regulated. There is some evidence to suggest that collagen supplements can help with restoring or preventing the deterioration of the cartilage in the joints. Though this study is promising, more research is necessary to fully determine the positive effects that collagen may have on muscle growth. One study found that (2016). Health Canada. The reasons why headaches are a potential side effect of collagen are variable and not necessarily conclusive, as more research is needed on this topic., However, one common trend we found in our research for this article is that the type of collagen and quality of the supplement itself contributes a lot to the potential for side effects like headaches., It has been considered that collagen may cause headaches for some users because it can raise your calcium levels. WebCollagen peptides are used as a bioactive ingredient in nutricosmetic products and have been shown in preclinical studies to improve skin barrier function, to induce the synthesis of collagen and hyaluronic acid, and to promote fibroblast growth and migration. 2019 Mar 4. Moskowitz RW. 2015;95(4):702-7. Clark KL, Sebastianelli W, Flechsenhar KR, et al. Reducing the stiffness of arteries can help promote heart health. SkinnyFit Super Youth Side Effects View abstract. Using a double-blind, independent group's design, 24 recreationally active males consumed either 20 g day-1 of CP or a placebo control (CON) for 7 days before and 2 days after performing 150 drop jumps. You can learn more about how we ensure our content is accurate and current by reading our. Oikawa SY, Kamal MJ, Webb EK, McGlory C, Baker SK, Phillips SM. From arthritis, to skin health, to post surgery healing, a quality collagen supplement can do wonders for your body. Chemical additives in collagen peptide supplements, such as anti-caking substances and preservatives are common causes of acne flare-ups in those who notice increased breakouts with collagen use. 2009;73(2):422-4. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. A person should always talk to their doctor before starting any new supplements or increasing the use of any existing supplement. Excessive collagen peptides can lead to a deficit in tryptophan, which causes your serotonin levels to lower. In some individuals, this can trigger the formation of kidney stones. Epub 2022 Dec 1. De Luca C, Mikhal'chik EV, Suprun MV, et al. MeSH Metabolites. There are also claims that collagen may provide additional health benefits. Therapeutic role of melatonin in migraine prophylaxis: A systematic review. Please enable it to take advantage of the complete set of features! Side Effects of Collagen Peptides on the Skin, Anti-Aging Alternatives to Collagen Peptides Supplements, Vitamin C for Acne Scars: Efficacy, How It Works, Before and Afters, Everything You Need To Know About Icon Laser by Cynosure, Vitamin C Serum for Acne: Benefits, How to Choose One, and How to Use It, Everything You Need To Know About PicoSure Laser by Cynosure, Vitamins for Acne: Do They Work? 2014;39(8):874-80. Pre-Bed Casein Protein Supplementation Does Not Enhance Acute Functional Recovery in Physically Active Males and Females When Exercise is Performed in the Morning. Therapeutic potential of novel glutamate receptor antagonists in migraine. Gold M. H. (2007). The review also showed that it helped reduce joint pain. Collagen | Uses, side-effects | Versus Arthritis Collagen peptide supplements usually come in the form of either powders or pills and are generally considered equally safe and effective for skin care purposes.